RYR2 and cancer: Dantrolene is a specific and currently the only effective treatment for malignant hyperthermia.[12] Interestingly, dantrolene has also shown to exert antiarrhythmic effects in animal models of CPVT1.[13–15] Dantrolene has been proposed to act through binding to the N-terminal parts of RyR1 and RyR2 and restoring inter-domain interactions critical for the closed state of the RyR2 Ca2+ channel.[16]