CASP4 and neoplasm: To further characterize gene expression in the Ad-GSCs and Sp-GSCs tumor xenografts, we examined the expression of genes previously defined to be characteristic of the Classical (FGFR3, PDFA, EGFR, AKT-2 and Nestin) and Mesenchymal (CHI3L1, TRADD, NF1, RelB and CASP4) glioblastoma subtypes [4].