Therefore, we decided to profile the autoimmune activities of 41 CSF-matched serum samples, collected from 5non-SLE, 26 NPSLE, and 10 non-NPSLE subjects, and compare the autoantibody titers between the matched CSF and serum samples by Z-score (Fig 4).We focused on anti-RPLP2 and anti-SS-A autoantibodies, because they had a relatively higher prevalence in CSF specimens of SLE patients. This evidence concerns the gene CALR and systemic lupus erythematosus.