STAT3 and colorectal carcinoma: With our data showing berberin inhibiting COX-2/PGE2 expression and JAK2/STAT3 signaling, as well as COX-2/PGE2 regulating JAK2/STAT3 pathway, we hypothesized that the mechanism of berberin’s inhibitory effect on CRC invasiveness and metastatic potential was its negative influence on the signaling axis of COX-2/PGE2-JAK2/STAT3.