Haplotype analyses of the CRHR1 gene in 2,533 unrelated Caucasian individuals identified one haplotype in the proximal block 1 and two haplotypes in the distal block 2 that showed nominally significant genotype – traumatic stress interactive effects on the likelihood of developing alcoholism (corrected P<0.025) (32). The gene discussed is CRHR1; the disease is alcohol dependence.