In the present study, three SNPs were identified in the coding region of the BMP15 gene, rs3810682 (−9C>G) and rs79377927 (788_789insTCT) in exon 1 and rs17003221 (852C>T) in exon 2, which were detected in patients with POF and the control individuals. Here, BMP15 is linked to premature menopause.