The c.985C>T missense mutation in the BMP15 gene, which was initially identified in Chinese females with POF in 2010 (38), has been found to result in alteration of the polar/positive amino acid, arginine, to the nonpolar and neutral amino acid, cysteine, which is located in the region of biologically active BMP15, and this c.985C>T variant has been reported to be an important potential disease associated mutation in BMP15 among patients with POF (38). This evidence concerns the gene BMP15 and premature menopause.