In the present study, single nucleotide polymorphisms (SNPs) of the growth differentiation factor 9 (GDF9), bone morphogenetic protein 15 (BMP15), inhibin βB (INHBB) and follicle stimulating hormone receptor (FSHR) genes were investigated in a Chinese Hui population in Ningxia, western China, and their association with POF was evaluated. This evidence concerns the gene FSHR and premature menopause.