BMP15 and premature menopause: However, Zhang et al (39) demonstrated rare mutations in BMP15 exons, and changes in the BMP15 pro-peptide in Chinese females with POF, and concluded that the two SNPs rs17003221 (CT) in exon 2 and rs (3810682CG: ss16336587) in the putative promoter region of exon 1 were not associated with POF.