INS and type 2 diabetes mellitus: Several studies using two step hyperinsulinemic-euglycemic clamps (steady-state insulin concentrations of half to 3-fold those seen in this study) in type 2 diabetic patients have shown daily treatment with pioglitazone (45 mg) for 4 months increased insulin-stimulated Rd by 17–44%, while also enhancing insulin-mediated suppression of EGP by [10, 11, 13, 15].