Multivariate analysis in intestinal tumors indicated R-status (HR: 2.78, 95% CI: 1.39–5.55, p = 0.004) and tumor stage (HR: 2.61, 95% CI: 1.28–5.30, p = 0.008) as independent prognostic factor but not NOTCH2 expression. This evidence concerns the gene NOTCH2 and neoplasm.