Analyzing the patients with NOTCH1-negative tumors for an association with survival in the subgroups of (a) early (pT1 + pT2) and advanced (pT3 + pT4) tumor stages separately, (b) in intestinal and non-intestinal-type tumors, and (c) in completely resected (R0) tumors only, revealed significant associations with NOTCH1-negative tumors and worse survival in patients with early tumor stages but not in patients with advanced tumors (plog-rank = 0.007 and plog-rank = 0.999, respectively) (Figures 4B,C). This evidence concerns the gene NOTCH1 and neoplasm.