SPP1 and metabolic dysfunction-associated steatotic liver disease: Mice fed a methionine-choline-deficient (MCD) diet, an animal model of nonalcoholic fatty liver disease, and depleted in NKT cells have significantly attenuated hedgehog and osteopontin expression and fibrosis suggesting that NKT cells promote fibrogenesis via osteopontin and hedgehog pathways [29].