APS is defined by arterial or venous thrombus, recurrent fetal loss, and thrombocytopenia with positive antibodies including lupus anticoagulant (LA), anticardiolipin antibodies (aCL), and antibodies to β2-glycoprotein-I (anti-β2GPI) [1, 2]. Here, ACLY is linked to autoimmune polyendocrinopathy.