In order to characterize the cardiac protein quality control profile during hypertension-induced compensated hypertrophy we evaluated E3 ubiquitin ligases Atrogin and MuRF-1, proteasomal α5/α7, β1, β5, and β7 subunits, and ALDH2 protein levels in heart homogenates from control, SHR, and SHRt. The gene discussed is TRIM63; the disease is hypertensive disorder.