In light of research that suggested that the dysfunction of DA, 5-HT, and glutamate is associated with maladaptive behavior in schizophrenia, the unique mechanism of action of TJ-54 whereby it exerts partial D2 agonistic, 5-HT1A agonistic, and 5-HT2A and glutamate antagonistic effects [9, 43] may prove to be important for both its effectiveness and tolerability in treatment-resistant schizophrenia [44]. Here, HTR2A is linked to schizophrenia.