On the other hand, a previous study showed that elderly patients with type 2 diabetes exhibited a significantly decreased GAS6 level but a significantly increased inflammatory marker-plasma CRP level compared to healthy individuals [17, 18], suggesting that the relationship between circulating GAS6 level and obesity-induced inflammation could be significantly affected by ageing and hyperglycemia. This evidence concerns the gene GAS6 and obesity due to melanocortin 4 receptor deficiency.