BMP7 and Ureteral obstruction: Hypothesis that BMP-7 possesses anti-fibrotic activity was first verified in a rat model of unilateral ureteral obstruction (UUO) (Hruska et al., 2000), based on previous observations that BMP-7 was a renal morphogen (Dudley et al., 1995), such that its loss and re-expression pattern mirrors preservation of renal function in acute renal injury (Vukicevic et al., 1998).