BMP7 and diabetic kidney disease: Under several disease states like ischemia-reperfusion injury (Simon et al., 1999), diabetic nephropathy (Wang et al., 2001), and hypertensive nephrosclerosis (Bramlage et al., 2010), BMP-7 has been reported to be down-regulated in the kidney, and increased again during the regenerative phase (Vukicevic et al., 1998; Simon et al., 1999).