• 45-year old Spanish man (Jimenez-Saenz and Martinez-Sanchez, 2006): Green tea infusion (6 cups/day) over 4 months. Asthenia and jaundice of ten days duration prior to cessation. ALT 1613 U/L (normal < 40) with R 4.3, ALT normalized within 2 months of cessation. Reexposure 6 weeks later: ALT 1460 U/L after 1 month of reuse. ALTb < 5N and ALTr = 2ALTb → positive reexposure. This evidence concerns the gene GPT and asthenia.