Similarly, the within-domain IIV did not vary as a function of APOE status in early AD [F(1,33) = 0.219; p = 0.67; η2 = 0.01], but there was a significant effect of APOE status in HCS [F(1,75) = 4.393; p = 0.04; η2 = 0.04] and aMCI [F(1,51) = 2.399; p = 0.05; η2 = 0.03], which indicated increased within-domain IIV in these groups. The gene discussed is APOE; the disease is Alzheimer disease.