Many chemotherapeutic agents elicit anti-tumor effects by stimulating ATP release from tumor cells (Martins et al., 2009), subsequently recruiting dendritic cells (Aymeric et al., 2010) and lymphocytes via P2X7 (an ATP purinergic receptor), and promote phagocytosis and autophagy (Michaud et al., 2011). This evidence concerns the gene P2RX7 and neoplasm.