Mutations and common genetic variants of the MAPT gene have been associated with the development of tauopathies as well as to imbalances in the 4R:3R tau isoform ratio which may contribute to tau hyperphosphorylation, aggregation and pathology (Anfossi et al., 2011; Spillantini and Goedert, 2013). Here, MAPT is linked to tauopathy.