Moreover, Sphk2 is the predominant S1P-synthesizing isoform expressed in brain tissues [51,52], and a recent work showed how FTY720 was rapidly taken up by human SH-SY5Y neuroblastoma cells and FTY720-P was generated in the nucleus by SphK2 [52], implying that phosphorylation of FTY720 may occur also in our neuronal and organotypic cultures. The gene discussed is SPHK2; the disease is neuroblastoma.