These studies have shown that mice deficient for either p16Ink4a or p19Arf, the murine homolog of human p14ARF, have increased susceptibility to asbestos-induced mesothelioma and that inactivation of both p16Ink4a or p19Arf cooperate to accelerate asbestos-induced tumorigenesis [30]. Here, CDKN2A is linked to mesothelioma.