Finally, many factors related to immune-mediated proteolysis and cell death, such as C1-esterase inhibitor (Serping1), lymphotoxin A (TNFβ, Lta), and lymphocyte cytosolic protein 2 (Lcp2), were identified as late responding mouse genes in the U251 and 9L models, while several cathepsins (Cts genes) were increased both at early and at late time points in both tumor models. The gene discussed is TTR; the disease is neoplasm.