Table 1 presents expression data for select examples of U251 tumor cell genes whose responses to metronomic CPA are beneficial to the overall therapeutic response, as well as genes whose responses are undesirable, e.g., induction of the tumor-promoting MMP13, the immune-inhibitory adhesion molecule CEACAM1, and the pro-metastatic factors LAMP3/CD208 and ACP5. This evidence concerns the gene MMP13 and neoplasm.