Metronomic CPA treatment also induced a core set of death-related genes that may be important for innate and/or adaptive immune activation by damaged tumor cells, including Sp110, Mx1, Mx2, Ebi3, Eomes, Tnfsf4, Gdf15, Ddx58, and Dhx58 (Figure 1A-C, Additional file 1: Tables S1 and S4 and Additional file 2: Figure S8B). This evidence concerns the gene DHX58 and neoplasm.