Mouse genes up-regulated in both tumor models (9L, and at least one of the U251 tumor time points) were enriched in gene clusters that include the following: immune response, lysosome, regulation of cytokine production, lectin/carbohydrate binding, cytokine receptor interaction, induction of programmed cell death, leukocyte activation, and regulation of immune effector process (Table 4A). This evidence concerns the gene EBI3 and neoplasm.