The first network shows tumoricidal and infectious disease-related NK factors, including granzymes A and B (Gzma, Gzmb), perforin (Prf1), Fas death receptor (Fas), Fas-mediated apoptosis gene Olr1, NK cell-expressed chemokine receptor Cxcr3 (the known interacting receptor for chemokines CXCL9, CXCL10, and CXCL11), MHC class I regulated NK marker Klrg1, interferon-activated genes (Ifi202b, Oas1), NK cell-expressed Ly6a and Sema4d, and lymphocyte-homing factors Stab2 and Nov (Figure 3B and Figure 3C). This evidence concerns the gene PRF1 and infectious disease.