The vascular endothelial growth factor-c/vascular endothelial growth factor receptor 3 (VEGF-C/VEGFR-3)-mediated invasion and metastasis of cancer cells was reported to elevate CNTN-1 expression through Src/p38 MAPK-C/EBP-dependent pathway, suggesting that CNTN-1 was a downstream effector of the VEGF-C/VEGFR-3 signal pathway in cancer cells (Su et al. 2006b). This evidence concerns the gene FLT4 and cancer.