Furthermore, this study demonstrated that CNTN-1 overexpression was closely correlated with EMT markers (E-cadherin, Slug and N-cadherin) changes proved by immunohistochemistry in primary lesion of patients with gastric cancer and that knockdown of CNTN-1 could reverse EMT markers alterations via silencing of Slug expression (not Snail) in gastric cancer MKN45 cells. This evidence concerns the gene CNTN1 and gastric cancer.