VEGFA and neoplasm: The decrease in HIF-1α levels in MCF-7 xenograft tumors could have a multipronged effect where it not only abates concerns about tumor aggressiveness caused by the severe hypoxic conditions generated by anti-angiogenic treatments but also increases the chances of vascular normalization by increasing pericyte coverage, since HIF-1α directly influences VEGF production and in turn antagonizes pericyte involvement with ECs by activating VEGFR2 and downregulating PDGFR-β signaling through a VEGFR2–PDGFR-β complex [60].