The expression of its target genes Ppp3cb and Kras were down-regulated, but eight target genes including YWHAH, TXNRD2, LDHA, ACE, EIF5B, SPARC, ITPRC, AND PCNA were up-regulated, and these targeted genes are related with several cancer signaling pathways including ERK/MAPK, PI3K/AKT, and 14-3-3 mediated signaling. This evidence concerns the gene SPARC and cancer.