A transcriptome analysis through RNA sequencing of the germinal zone of the human fetal neocortex at 13-16 gestational weeks revealed a higher expression of CASC5 in the ventricle zone compared the sub ventricle zone and cortical plate; this finding further confirmed the effect of mutated CASC5 on proliferating cells in the ventricle zone that cause microcephaly [43,44]. The gene discussed is KNL1; the disease is microcephaly.