MC4R and type 2 diabetes mellitus: Of the 7 SNPs previously shown to be associated with type 2 diabetes in European GWAS un-stratified analyses; rs12571751 in ZMIZ1, rs10842994 near KLHDC5, rs2796441 near TLE1, rs459193 near ANKRD55, rs10401969 in CILP2, rs12970134 near MC4R and rs7202877 near BCAR1 [16], all 7 SNPs had the same direction of effect (odds ratio > 1.0 adjusted for sex, age and BMI) as in the original reports (p = 7.81 × 10–3, binomial test, Table 3, S2 Table).