ZMIZ1 encodes a member of the PIAS (protein inhibitor of activated STAT) family proteins, which interact with p53 [38], and a recent report using β-cell specific p53 deleted mice showed that p53 depletion could prevent glucotoxic β-cell death in these mice [39]; therefore, ZMIZ1 might be involved in β-cell death through p53 activation and contribute to conferring susceptibility to type 2 diabetes. The gene discussed is ZMIZ1; the disease is type 2 diabetes mellitus.