In this study, we examined the association of 7 SNPs, rs12571751 in ZMIZ1, rs10842994 near KLHDC5, rs2796441 near TLE1, rs459193 near ANKRD55, rs10401969 in CILP2, rs12970134 near MC4R, and rs7202877 near BCAR1, with susceptibility to type 2 diabetes in a Japanese population, and found that rs12571751 in ZMIZ1 was significantly associated with type 2 diabetes in the Japanese population. This evidence concerns the gene ZMIZ1 and type 2 diabetes mellitus.