INS and type 2 diabetes mellitus: Furthermore, the risk allele of rs11063069 was significantly associated with a decrease of HOMA-β in male (p = 0.0048 adjusted for age and BMI; Table 7); therfore, the risk allele of CCND2 might have some effects on the decrease of insulin secretion, and on conferring susceptibility to type 2 diabetes in male, as reported in the original European GWAS.