Moreover, this study has revealed a possible role of CD70/CD27 signaling in immune escape in NSCLC, since 90% of biopsies were infiltrated by CD27+ lymphocytes in the microenvironment of the tumor and showed a trend towards increased FOXP3 expression and higher CD4/CD8 ratios surrounding CD70+ tumor cells. Here, CD27 is linked to non-small cell lung carcinoma.