COL18A1 and hypertensive disorder: As hypertension is strictly associated with inflammation [9–11], besides potent physiological regulators of angiogenesis such as angiogenin, endostatin or basic fibroblast growth factor (bFGF) [12–21], we studied mediators which activity is significantly increased during inflammation like vascular endothelial growth factor (VEGF) and interleukin 8 (IL-8) [22–32].