Hepatic HO-1 protein levels are increased in the liver in patients with NASH relative to steatosis-positive controls [96], and there are reports of increased HO-1 mRNA, protein and/or activity in the livers of rodents with NAFLD [74,97,98]; yet other preclinical studies do not support these findings [99,100,101]. The gene discussed is HMOX1; the disease is metabolic dysfunction-associated steatohepatitis.