Preliminary in vitro experiments confirm that UDCA can induce cancer cell apoptosis by promoting caspase-3, caspase-8, caspase-9, Bax, Fas/FasL, TRAIL, DR4, DR5 and IκB-α gene expression in cancer cells, and reduce the expression of Bcl-2, Bcl-xL, XIAP, cIAP-1, cIAP-2, survivin and NF-κB. This evidence concerns the gene NFKB1 and cancer.