We also examined the remaining promoter region (-492/+115 bp) after deletion of the six TBEs for the presence of binding sites of other transcription factors, such as AP-2, C2H2 zinc finger, E2F4, EGR1, ETS1, and serum response factors (data not shown), several of which are known to play an important role in colon cancer. The gene discussed is E2F4; the disease is colonic neoplasm.