Colorectal cancers show dysregulation of the Wnt/β-catenin signaling pathway, including Wnt-dependent transcription of c-Myc and CyclinD1. Our previous work showed that ALDH1B1 is a potential biomarker for colon cancer and the expression pattern of this protein is suggestive of a close association of ALDH1B1 with the activation of Wnt/β-catenin signaling, a crucial pathway for colon cancer generation. The gene discussed is CCND1; the disease is malignant colon neoplasm.