Haploinsufficiency of CYFIP1 at 15q11.2 [97], CHRNA7 at 15q13.3 [98], NDE1 at 16p13.11 [99] and PRRT2 at 16p11.2 [100] has been implicated as risk-conferring mechanism for epilepsy and other neurodevelopmental phenotypes [88,89,91]. Here, CYFIP1 is linked to epilepsy.