NFATC3 and age-related macular degeneration: We observed an AMD-associated SNP in NFATC3. NFATC3 is dephosphorylated by calcineurin in response to intracellular calcium—an increased calcium status permits fluent transmission of nuclear signals to which NFATC3 may localize; the result is an accumulation of NFATC3 in the nucleus.