Pathway-based analysis demonstrated robust enrichment of netrin-1 pathway constituents with AMD-associated SNPs—particularly in a sub-pathway acting, after netrin-1 binding of DCC, through a 3'-5'-cyclic adenosine monophosphate (cAMP)-calcineurin (CN)- nuclear factor of activated T-cells (NFAT) axis (Fig 1). Here, NTN1 is linked to age-related macular degeneration.