CEBPA and acute promyelocytic leukemia: Furthermore, all-trans retinoic acid (ATRA) can induce differentiation of CSCs in acute promyelocytic leukemia (APL) via C/EBP factors [16,17], wild type transcription factors, such as, C/EBPα, can induced differentiation in human AML and in lung cancer cell lines and in mouse in vivo models [17,18,19,20].