Previous reports show that activation of RLR induces TRAIL, Noxa and Puma, but the expression of these genes was independent of the cancerous properties.12 In our experiment, we found that the over-expression of IPS-1 promoted the induction of the pro-apoptotic gene TRAIL, which has been reported to have an important role in the induction of apoptosis in various types of cancers. The gene discussed is PMAIP1; the disease is cancer.