IFNB1 and cancer: In contrast, NDV infection in IFNAR1-lacking cells (MDAMB-231) the production of IFNβ is severely reduced due to absence IFNAR1 signaling pathway via IFNAR1 which promotes NDV replication leading to more HN protein and therefore induces strong induction of TRAIL but very low induction of type I IFNs, which further promoted the death of the cancer cells.