Malignant pleural mesothelioma (MPM) is sensitive to phosphatidylinositol 3-kinase/mammalian target of rapamycin (PI3K/mTOR) signaling inhibitors due to the activation of PI3K/mTOR signaling.1, 2 The activation may result from inactivation of INP4A phosphatase, which is downregulated in 44% of MPM (presented at IMIG2014), or alterations in PI3K signaling components, which are mutated in 9% of MPM,3 while receptor tyrosine kinase mutations/amplifications have not been identified in two recent high-throughput studies.4, 5. Here, MTOR is linked to malignant pleural mesothelioma.