Reduced miR-30 levels have been associated with myocardial matrix remodeling and with angiotensin II-induced hypertrophy.31, 55 Low miR-30e expression was also detected in myocardial tissue from patients with dilated cardiomyopathy and aortic stenosis.56 However, the specific myocardial expression of miR-30 in the context of exposure to DOX and its downstream mechanisms had not been previously demonstrated. The gene discussed is AGT; the disease is aortic stenosis.