Thioridazine is known to target dopamine receptors in patients with schizophrenia and psychosis.28, 29 We sought to investigate whether different phenothiazine derivatives (thioridazine, trifluoperazine, prochlorperazine and fluphenazine) might affect dopamine receptor D2 (DRD2) expression in GBM cells. This evidence concerns the gene DRD2 and psychotic disorder.