The protective effect of GIT27 on renal function in T2D is supported by a previous study in diabetic db/db mice, where long-term GIT27 administration decreased albuminuria and glomerulosclerosis.45 The clinical significance of our data is corroborated by the observation that in cultured podocytes, downregulation of PDK1 and increase in apoptosis, induced by T1D patient sera with high LPS activity, was prevented by GIT27. This evidence concerns the gene PDK1 and glomerulosclerosis.