Recently, a new strategy targeting multiple kinases was proposed for cancer treatment.41, 42, 43 Our previous findings have shown that targeting gankyrin significantly blocked tumor-initiating cell-mediated tumor cell expansion and metastasis.9, 11 In light of our studies, a combination of gankyrin and Rac1/JNK targeting may profoundly improve liver cirrhosis therapies. The gene discussed is PSMD10; the disease is cancer.