Downregulation of GLP-1 and GIP receptor expression in hyperglycemia have been reported in our previous studies9 as well as other publications.25, 26 Interestingly, here we observed that geniposide can upregulate GLP-1R expression, which may explain the different effects of ICG001 and exendin (9–39) on the effect of geniposide. The gene discussed is GLP1R; the disease is Hyperglycemia.