We observed that cPAF increased the expression of phosphorylated p53 at S392 (Figure 5e), probably enhancing its binding capacity to the promoter region of p21 as described by Kapoor and Lozano.40 Taken together, these findings unravel a novel and yet undiscovered role of cPAF on key proteins critical for cell proliferation that indicate a potential role in tumor suppressor mechanisms. The gene discussed is TP53; the disease is neoplasm.