NEO1 and Stroke: RGMa is upregulated in the penumbra of human patients who died of stroke.6 Interestingly, electrical stimulation downregulates RGMa expression, which correlates with an improved functional outcome following middle cerebral artery occlusion (MCAO).7, 8 Although Neogenin has been shown to be expressed in the injured brain following stroke,9 there is no direct evidence that it may have a role in the pathology of this disease.