14-3-3 Proteins are a highly conserved group of molecules having pivotal roles in apoptosis, intracellular trafficking, cell cycle control and signal transduction, which modulate the interaction between components of signal transduction pathways.59 They are abundant in neurons (up to 1% of the total soluble protein in the brain), and were found in the cerebrospinal fluid of patients with cerebellar disorders,60 suggesting their possible use as biomarker of neuronal damage. This evidence concerns the gene YWHAQ and cerebellar disorder.