Besides the established role in cell death, the Drosophila JNK pathway is also required for cell migration and tumor metastasis.2, 34, 41 Consistent with this notion, loss of DLK, the mammalian ortholog of Wnd, results in delayed radial migration of neuronal cells.42 Therefore, a potential role of Wnd in regulating cell migration and tumor metastasis is worth further investigation. Here, MAPK8 is linked to neoplasm.