ALK and anaplastic large cell lymphoma: Indeed, ALK-expressing tumors present an oncogene addiction and die by apoptosis following ALK downregulation.27, 28 Moreover, despite different subcellular localization of oncogenic ALK forms (nuclear and cytoplasmic for NPM–ALK,25 cytoplasmic and at the plasma membrane for ALK,29 respectively) (Supplementary Figure 1), P36 killed both ALCL and neuroblastoma cells.