Previous studies have found that the mechanisms by which tumor cells develop drug resistance include reduced drug absorption, increased drug efflux through the ABC (ATP-binding cassette) transporter protein, enhanced tumor cell ability to detoxify anticancer drugs through the reductase system, reduced tumor apoptosis rate through regulating the apoptosis pathway, and modulation of cytokine production to alter the tumor microenvironment and signaling pathways [7]. Here, ABCA4 is linked to neoplasm.