In line with their increased lung inflammation, lung IFN-γ levels of were significantly increased in TNF-α deficient mice at 1 month post infection as compared to WT mice, as well as in IL-1RI deficient as compared to WT mice at 4 months, while IL-36R deficient mice exhibited IFN-γ levels similar to WT controls. The gene discussed is TNF; the disease is infection.