Interestingly, 5 patients displayed very high levels of BAFF in their serum (Figure 3) and 3 of them also displayed severe autoimmune manifestations (autoimmune hemolytic anemia, lupus like symptoms with high levels of antinuclear and antiphospholipid antibodies, and vasculitis with high levels of antinuclear and anti-neutrophil cytoplasmic antibodies, resp). The gene discussed is TNFSF13B; the disease is vasculitis.