MAPT and Alzheimer disease: Among the known phosphorylation sites, Y18, S68, T69, T71, S113, T123, T153, T175, T184, S185, S191, and Y197 in the N-terminal region, S208, S210, S214, S237, and S238 in the proline-rich domain, S258, S262, S289, and S356 in the microtubule binding domain as well as Y394, T403, S409, S422, T427, S433, and S435 in the C-terminal region (numbered in isoform 2 of tau, 441 amino acids) are phosphorylated in AD brains but not in normal brains [10, 17].